The insect cell/baculovirus expression vector system (BEVS) is becoming increasingly popular for the production of recombinant proteins. 

The system offers a number of advantages, including:

  • Ability to perform complex post-translational modifications (PTMs)
  • High success rate of soluble protein recovery
  • Suitable for the production of large protein complexes, e.g. virus like particles (VLPs)
  • High protein expression levels compared to other higher eukaryotes

One of the main drawbacks of the system is longer timeframes for protein expression in comparison to other host systems.