Dr Christian Fercher
Operations Manager
Protein Expression Facility
+61 7 3346 3498
Operations Manager
Expertise
- Structural biology and protein characterisation
- Microbial and mammalian recombinant protein production
- Antibody engineering and production
- Downstream process development
- Project design and management
Journal Articles
Bloxham, Conor J., Hulme, Katina D., Fierro, Fabrizio, Fercher, Christian, Pegg, Cassandra L., O'Brien, Shannon L., Foster, Simon R., Short, Kirsty R., Furness, Sebastian G. B., Reichelt, Melissa E., Niv, Masha Y. and Thomas, Walter G. (2024). Cardiac human bitter taste receptors contain naturally occurring variants that alter function. Biochemical Pharmacology, 219 115932, 115932. doi: 10.1016/j.bcp.2023.115932
Islam, Jiaul, Conroy, Paul, Fercher, Christian, Kim, Mijin, Yaari, Zvi, Jones, Martina, Bell, Toby D. M., Caradoc-Davies, Tom, Law, Ruby, Whisstock, James, Heller, Daniel, Mahler, Stephen and Corrie, Simon (2023). Design of polarity-dependent immunosensors based on the structural analysis of engineered antibodies. ACS Chemical Biology, 18 (8), 1863-1871. doi: 10.1021/acschembio.3c00303
Panagides, Nadya, Zacchi, Lucia F., Souza, Mitchell J. De, Morales, Rodrigo A. V., Karnowski, Alexander, Liddament, Mark T., Owczarek, Catherine M., Mahler, Stephen M., Panousis, Con, Jones, Martina L. and Fercher, Christian (2022). Evaluation of phage display biopanning strategies for the selection of anti-cell surface receptor antibodies. International Journal of Molecular Sciences, 23 (15) 8470, 8470. doi: 10.3390/ijms23158470
Honer, Jonas, Niemeyer, Katie M., Fercher, Christian, Diez Tissera, Ana L., Jaberolansar, Noushin, Jafrani, Yohaann M. A., Zhou, Chun, Caramelo, Julio J., Shewan, Annette M., Schulz, Benjamin L., Brodsky, Jeffrey L. and Zacchi, Lucía F. (2021). TorsinA folding and N-linked glycosylation are sensitive to redox homeostasis. Biochimica et Biophysica Acta. Molecular Cell Research, 1868 (9) 119073, 119073. doi: 10.1016/j.bbamcr.2021.119073
Fercher, Christian, Jones, Martina L., Mahler, Stephen M. and Corrie, Simon R (2021). Recombinant antibody engineering enables reversible binding for continuous protein biosensing. ACS Sensors, 6 (3) acssensors.0c01510, 764-776. doi: 10.1021/acssensors.0c01510
Fercher, Christian and Zacchi, Lucía F. (2020). Resolving the TorsinA Oligomerization Conundrum: The Glycan Hypothesis. Frontiers in Molecular Biosciences, 7 585643, 585643. doi: 10.3389/fmolb.2020.585643
Niamsuphap, Suchada, Fercher, Christian, Kumble, Sumukh, Huda, Pie, Mahler, Stephen M. and Howard, Christopher B. (2020). Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets. Expert Opinion on Drug Delivery, 17 (9), 1189-1211. doi: 10.1080/17425247.2020.1781088
Nazir, Yasir, Saeed, Aamer, Rafiq, Muhammad, Afzal, Samina, Ali, Anser, Latif, Muhammad, Zuegg, Johannes, Hussein, Waleed M., Fercher, Christian, Barnard, Ross T., Cooper, Matthew A., Blaskovich, Mark A.T., Ashraf, Zaman and Ziora, Zyta M. (2020). Hydroxyl substituted benzoic acid/cinnamic acid derivatives: tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies. Bioorganic and Medicinal Chemistry Letters, 30 (1) 126722, 1-5. doi: 10.1016/j.bmcl.2019.126722
Yuan, Ye, Jin, Wanli, Nazir, Yasir, Fercher, Christian, Thomas Blaskovich, Mark A., Cooper, Matthew A., Barnard, Ross T. and Ziora, Zyta M. (2019). Tyrosinase inhibitors as potential antibacterial agents. European Journal of Medicinal Chemistry, 187 111892, 111892. doi: 10.1016/j.ejmech.2019.111892
Islam, Jiaul, Riley, Blake T., Fercher, Christian, Jones, Martina L., Buckle, Ashley M., Howard, Christopher B., Cox, Rosalind P., Bell, Toby D. M., Mahler, Stephen and Corrie, Simon R. (2019). Wavelength-dependent fluorescent immunosensors via incorporation of polarity indicators near the binding interface of antibody fragments. Analytical Chemistry, 91 (12), 7631-7638. doi: 10.1021/acs.analchem.9b00445
Kohler, Verena, Goessweiner-Mohr, Nikolaus, Aufschnaiter, Andreas, Fercher, Christian, Probst, Ines, Pavkov-Keller, Tea, Hunger, Kristin, Wolinski, Heimo, Büttner, Sabrina, Grohmann, Elisabeth and Keller, Walter (2018). TraN: a novel repressor of an Enterococcus conjugative type IV secretion system. Nucleic Acids Research, 46 (17), 9201-9219. doi: 10.1093/nar/gky671
Fercher, Christian, Keshvari, Sahar, McGuckin, Michael A and Barnard, Ross T (2017). Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins. Experimental biology and medicine (Maywood, N.J.), 243 (2), 166-183. doi: 10.1177/1535370217748575
Resch, Yvonne, Blatt, Katharina, Malkus, Ursula, Fercher, Christian, Swoboda, Ines, Focke-Tejkl, Margit, Chen, Kuan-Wei, Seiberler, Susanne, Mittermann, Irene, Lupinek, Christian, Rodriguez-Dominguez, Azahara, Zieglmayer, Petra, Zieglmayer, René, Keller, Walter, Krzyzanek, Vladislav, Valent, Peter, Valenta, Rudolf and Vrtala, Susanne (2016). Molecular, structural and immunological characterization of Der p 18, a chitinase-like house dust mite allergen. PLoS one, 11 (8), e0160641. doi: 10.1371/journal.pone.0160641
Fercher, Christian, Probst, Ines, Kohler, Verena, Goessweiner-Mohr, Nikolaus, Arends, Karsten, Grohmann, Elisabeth, Zangger, Klaus, Meyer, N. Helge and Keller, Walter (2016). VirB8-like protein TraH is crucial for DNA transfer in Enterococcus faecalis. Scientific Reports, 6 (1) 24643. doi: 10.1038/srep24643
Fercher, Christian, Keller, Walter, Zangger, Klaus and Meyer, N. Helge (2016). H-1, N-15 and C-13 chemical shift assignment of the Gram-positive conjugative transfer protein TraH(pIP501). Biomolecular NMR Assignments, 10 (1), 163-166. doi: 10.1007/s12104-015-9658-3
Goessweiner-Mohr, Nikolaus, Eder, Markus, Hofer, Gerhard, Fercher, Christian, Arends, Karsten, Birner-Gruenberger, Ruth, Grohmann, Elisabeth and Keller, Walter (2014). Structure of the double-stranded DNA-binding type IV secretion protein TraN from Enterococcus. Acta Crystallographica Section D Biological Crystallography, 70 (9), 2376-2389. doi: 10.1107/s1399004714014187
Goessweiner-Mohr, Nikolaus, Fercher, Christian, Arends, Karsten, Birner-Gruenberger, Ruth, Laverde-Gomez, Diana, Huebner, Johannes, Grohmann, Elisabeth and Keller, Walter (2014). The type IV secretion protein TraK from the Enterococcus conjugative plasmid pIP501 exhibits a novel fold. Acta Crystallographica Section D Biological Crystallography, 70 (4), 1124-1135. doi: 10.1107/s1399004714001606
Arends, Karsten, Celik, Ertugrul-Kaan, Probst, Ines, Goessweiner-Mohr, Nikolaus, Fercher, Christian, Grumet, Lukas, Soellue, Cem, Abajy, Mohammad Yaser, Sakinc, Tuerkan, Broszat, Melanie, Schiwon, Katarzyna, Koraimann, Guenther, Keller, Walter and Grohmann, Elisabeth (2013). TraG encoded by the pIP501 type IV secretion system Is a two-domain peptidoglycan-degrading enzyme essential for conjugative transfer. Journal of Bacteriology, 195 (19), 4436-4444. doi: 10.1128/JB.02263-12
Goessweiner-Mohr, Nikolaus, Fercher, Christian, Abajy, Mohammad Yaser, Grohmann, Elisabeth and Keller, Walter (2012). Crystallization and first data collection of the putative transfer protein TraN from the Gram-positive conjugative plasmid pIP501. Acta Crystallographica Section F Structural Biology and Crystallization Communications, 68 (11), 1402-1405. doi: 10.1107/s174430911204184x
Conference Papers
Keller, Walter, Kohler, Verena, Goessweiner-Mohr, Nikolaus, Aufschnaiter, Andreas, Fercher, Christian, Probst, Ines, Pavkov-Keller, Tea, Hunger, Kristin and Wolinskiv, Heimo (2018). Crystal structure of TraN, a regulator of conjugative DNA-transfer, in complex with its cognate DNA binding site. 31st European Crystallographic Meeting, Oviedo, Spain, 23-27 August 2018. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1107/S2053273318094743
Goessweiner-Mohr, N., Fercher, C., Celik, E. -K., Arends, K., Grohmann, E. and Keller, W. (2011). Gram-positive bacterial conjugation: new structural insight on plasmid pIP501. CHESTER: INT UNION CRYSTALLOGRAPHY.