Dr Sheena Chua
Research Specialist - Analytics and Characterisation
Protein Expression Facility
+61 7 3346 3498
Research Specialist - Analytics and Characterisation
Expertise
- Protein analytics and characterisation to ensure quality and consistency
Journal Articles
Wizrah, Maha S. I., Chua, Sheena M. H., Luo, Zhenyao, Manik, Mohammad K., Pan, Mengqi, Whyte, Jessica M. L., Robertson, Avril A. B., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2022). AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. Journal of Biological Chemistry, 298 (10) 102453, 102453. doi: 10.1016/j.jbc.2022.102453
Erpf, Paige E., Chua, Sheena M.H., Phung, Toan K., Kerr, Edward D., Rothnagel, Joseph A., Schulz, Benjamin L. and Fraser, James A. (2022). Identification and characterisation of sPEPs in Cryptococcus neoformans. Fungal Genetics and Biology, 160 103688, 103688. doi: 10.1016/j.fgb.2022.103688
Chua, Sheena M. H., Wizrah, Maha S. I., Luo, Zhenyao, Lim, Bryan Y. J., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2021). Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets. Journal of Biological Chemistry, 297 (4) 101091, 101091. doi: 10.1016/j.jbc.2021.101091
Chua, Sheena M. H. and Fraser, James A. (2020). Surveying purine biosynthesis across the domains of life unveils promising drug targets in pathogens. Immunology and Cell Biology, 98 (10), 819-831. doi: 10.1111/imcb.12389
Spencer, Garrick W.K., Chua, Sheena M.H., Erpf, Paige E., Wizrah, Maha S.I., Dyba, Taylor G., Condon, Nicholas D. and Fraser, James A. (2020). Broadening the spectrum of fluorescent protein tools for use in the encapsulated human fungal pathogen Cryptococcus neoformans. Fungal Genetics and Biology, 138 103365, 103365. doi: 10.1016/j.fgb.2020.103365
Garcia, Mario D., Chua, Sheena M. H., Low, Yu-Shang, Lee, Yu-Ting, Agnew-Francis, Kylie, Wang, Jian-Guo, Nouwens, Amanda, Lonhienne, Thierry, Williams, Craig M., Fraser, James A. and Guddat, Luke W. (2018). Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proceedings of the National Academy of Sciences of the United States of America, 115 (41), E9649-E9658. doi: 10.1073/pnas.1809422115
Arras, Samantha D. M., Chua, Sheena M. H., Wizrah, Maha S. I., Faint, Joshua A., Yap, Amy S. and Fraser, James A. (2016). Targeted genome editing via CRISPR in the pathogen Cryptococcus neoformans. PloS One, 11 (10) e0164322, e0164322. doi: 10.1371/journal.pone.0164322
Thesis
Chua, Sheena Mei Hui (2021). Targeting metabolic pathways for new antifungals: purine biosynthesis. PhD Thesis, School of Chemistry and Molecular Biosciences , The University of Queensland. doi: 10.14264/feb5163